Diffuse and nodular glomerulosclerosis is the classic appearance of diabetic glomerulopathy. Note the variability in mesangial areas in this one glomerulus. Some show only mesangial matrix increase while others demonstrate nodule formation. This section is stained with silver methenamine Masson Trichrome (SMMT). With this stain, the mesangium is black indicating that it is all matrix increase with no immune complex type deposits and no infiltrative processes such as amyloid or the fibrils of fibrillary glomerulopathy among others. (SMMT 400x)
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