This image (Jones silver stain) shows prominent glomerulitis in an allograft kidney biopsy, characterized in this case by increased mononuclear cells and segmental endothelial cell swelling within glomerular capillary loops. The patient is a young adult man who had received a renal transplant approximately eight years ago and was found to have an elevated serum creatinine. In the transplant setting, glomerulitis and peritubular capillaritis represent forms of microvascular inflammation which are used to help establish a morphologic diagnosis of both acute/active and chronic/active antibody-mediated rejection.
Reference:
Haas M. An updated Banff schema for diagnosis of antibody-mediated rejection in renal allografts. Curr Opin Organ Transplant. 2014 Jun; 19(3):315-22.
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