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T. David Bourne, MD renal pathologist and neuropathologist at arkana laboratories
By David Bourne, MD

Oct 11, 2017


This glomerulus is large! Glomerular enlargement, or glomerulomegaly, may be diagnosed when a glomerulus sectioned through the hilum fills greater than 50% of a 40x microscopic field. It is thought to be a morphologic marker of glomerular hyperfiltration. While not specific, glomerulomegaly is often seen in patients with obesity-related glomerulopathy, in which case there is often the additional finding of focal segmental glomerulosclerosis. More recently, Salvatore and colleagues found glomerulomegaly in association with either diffuse mesangial or nodular glomerulosclerosis in all patients with chronic renal insufficiency and proteinuria who had a prolonged history of smoking and hypertension (see reference).

Salvatore SP, Troxell ML, Hecox D, Sperling KR, Seshan SV. Smoking-related glomerulopathy: expanding the morphologic spectrum. Am J Nephrol. 2015;41(1):66-72. PMID: 25659349


Quick note: This post is to be used for informational purposes only and does not constitute medical or health advice. Each person should consult their own doctor with respect to matters referenced. Arkana Laboratories assumes no liability for actions taken in reliance upon the information contained herein.