A patient with nephrotic-range proteinuria and declining renal function underwent total nephrectomy for a conventional clear cell renal cell carcinoma (Fig 1). In the non-neoplastic kidney tissue, focal segmental glomerulosclerosis with collapsing features was present (Fig 2). Careful evaluation of the adjacent non-neoplastic kidney can provide important clues to current or potential causes of decreased renal function in patients who undergo nephrectomy. Here, Bonsib and Pei discuss the topic of evaluating non-neoplastic kidney in tumor nephrectomy specimens:https://www.ncbi.nlm.nih.gov/pubmed/20574169.
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