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April 26, 2017

Anti-Glomerular Basement Membrane

A 19-year-old Caucasian male patient presented with acute renal failure. Serum creatinine was 4.9 mg/dL and he had hematuria and non-nephrotic range proteinuria. Anti-GBM serologic testing was positive. No ANCA detected. Figure 1 one shows a cellular crescent filling Bowman’s space. Figure 2 also shows a cellular crescent associated with a prominent break in Bowman’s capsule (red arrow). Immunofluorescence shows global linear IgG staining of the capillary walls (Figure 3).