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AA Amyloidosis, glomerular crescent
Renal Review

Case 2: A Crescentic Conundrum

The patient is a 75-year-old female with a history of hypertension who presents with acute kidney injury. Her serum creatinine…

Disintegrating Capillary Loop

Disintegrating Capillary Loop Riddled with Microperformations

This acellular scanning EM shows disintegrating capillary loop riddled with microperformations in a patient with crescentic glomerulonephritis. Photo credits to…

ANCA-associated vasculitis
Diagnose This!

Diagnose This (January 24, 2022)

In a patient with RPGN and this morphological finding on biopsy, what is the most likely diagnosis? …

Linear GBM Poll
Twitter Poll

Twitter Poll (April 28, 2021)

Answer: A, Linear GBM   Anti-GBM disease is classically characterized by bright linear staining with IgG by immunofluorescence. By light…

Anti-GBM disease, twitter poll, arkana laboratories
Twitter Poll

Twitter Poll (December 11, 2019)

Answer: D, All of the Above Anti-GBM disease presents with rapidly progressive glomerulonephritis (GN) with or without pulmonary hemorrhage. On…

By Vanessa Moreno, MD
Anti-GBM in renal biopsy at Arkana Laboratories
Twitter Poll

Twitter Poll (August 22, 2018)

ANSWER: D Anti-GBM disease is a rare small vessel vasculitis that affects glomerular and pulmonary capillaries. The majority of patients…

By Vanessa Moreno, MD

ANCA-Associated GN
Twitter Poll

Twitter Poll (February 21, 2018)

ANSWER: D ANCA-associated GN and anti-GBM GN are the most common causes of pulmonary-renal syndrome accounting for about 90% of…

By Vanessa Moreno, MD
Approximately 25-30% of the patients with anti-GBM crescentic glomerulonephritis are ANCA positive
Twitter Poll

Twitter Poll (February 1, 2018)

ANSWER: C Approximately 25-30% of the patients with anti-GBM crescentic glomerulonephritis are ANCA positive, usually for MPO-ANCA.

By Vanessa Moreno, MD
Anti-GBM Glomerulonephritis
Twitter Poll

Twitter Poll (November 8, 2017)

ANSWER: B The characteristic immunofluorescence staining on Anti-GBM Glomerulonephritis is strong and linear IgG along glomerular basement membranes.

By Vanessa Moreno, MD

anti GBM disease
Teaching Points

Anti GBM Disease

This biopsy from an 80-year-old male with acute kidney injury shows glomeruli with frequent rupture of the capillary loops and…

Anti-GBM (Anti-Glomerular Basement Membrane)
Teaching Points


A 19-year-old Caucasian male patient presented with acute renal failure. Serum creatinine was 4.9 mg/dL and he had hematuria and…

Anti-Glomerular Basement Membrane Disease
Pushing Glass

Pushing Glass (March 14, 2017)

The patient is a 61-year-old female who presents with hematuria and a creatinine of 6.23 mg/dL (baseline creatinine of 1.17…