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Type 1 Cryoglobulinemic Glomerulonephritis
The patient is a 75 year-old female who presents with proteinuria, a necrotic skin lesion on her lower extremity, and…
Waldenström’s Macroglobulinemia
A 57-year-old white male presents with fatigue, mild proteinuria, and a creatinine of 1.5 mg/dL. He was diagnosed with lymphoplasmacytic…
KDIGO Connections: HCV-Associated Kidney Disease
How do you treat patients with hepatitis C-associated kidney disease?
Cryoglobulinemic Glomerulonephritis
The patient is a 60-year-old male who presents with proteinuria, hematuria, and a creatinine of 2.8 mg/dL. He was in…
Twitter Post (August 30, 2018)
ANSWER: B Type II (mixed) cryoglobulinemia is characterized by immune-complexes containing a monoclonal Ig (usually IgM) that have an RF…
Twitter Poll (June 20, 2018)
ANSWER: D While the majority of cryoglobulinemic GNs do not show ultrastructural organization in deposits by EM, classically described deposits…
Twitter Poll (April 4, 2018)
ANSWER: B Mixed cryoglobulinemia is most commonly caused by hepatitis C virus (HCV), with some cases caused by lymphoproliferative or…
Hep C-Associated Cryoglobulinemic Glomerulonephritis
This biopsy was performed on a 66-year-old Caucasian male with a history of hepatitis C, who presented with nephrotic range…
Pushing Glass (January 12, 2018)
A 70-year-old female presents with 8 grams of proteinuria and a creatinine of 2.1. She relays that she has noticed…
Cryoglobulinemic Intimal Arteritis
This photomicrograph shows an artery with intimal edema and inflammation in a renal biopsy from a 56-year-old male with renal…
Cryoglobulinemic Deposits by EM
Electron microscopy can be helpful in the diagnosis of cryoglobulinemic glomerulonephritis. This renal biopsy (Fig. 1) shows a membranoproliferative pattern…
Diagnose This! (August 28, 2017)
What is this finding and what is the most likely etiology? …
Waldenstrom Macroglobulinemia
In this image of a combined silver-trichrome stain, the arrow points to the abnormal material within the arteriole lumen. This…