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Sjögren Syndrome, Diagnose This, Arkana Laboratories, renal pathology
L. Nich Cossey, MD
By L. Nich Cossey, MD
Type 1 Cryoglobulinemic Glomerulonephritis, arkana laboratories
Teaching Points

Type 1 Cryoglobulinemic Glomerulonephritis

The patient is a 75 year-old female who presents with proteinuria, a necrotic skin lesion on her lower extremity, and…

Waldenström's Macroglobulinemia, arkana laboratories, teaching points for renal pathology, kidney biopsy
Teaching Points

Waldenström’s Macroglobulinemia

A 57-year-old white male presents with fatigue, mild proteinuria, and a creatinine of 1.5 mg/dL. He was diagnosed with lymphoplasmacytic…


HCV- Associated Kidney Disease, KDIGO Connections, kidney disease, renal pathology
KDIGO Connections

KDIGO Connections: HCV-Associated Kidney Disease

How do you treat patients with hepatitis C-associated kidney disease?    

Acute kidney injury, chryoglobulinemia, glomerulonephritis, hyaline thrombi, masked deposits, paraffin immunofluorescence, Cryoglobulinemic Glomerulonephritis
Teaching Points

Cryoglobulinemic Glomerulonephritis

The patient is a 60-year-old male who presents with proteinuria, hematuria, and a creatinine of 2.8 mg/dL. He was in…

Type II Cryoglobulinemia
Twitter Poll

Twitter Post (August 30, 2018)

ANSWER: B Type II (mixed) cryoglobulinemia is characterized by immune-complexes containing a monoclonal Ig (usually IgM) that have an RF…

Vanessa Moreno, MD
By Vanessa Moreno, MD

cryoglobulinemic GN’s
Twitter Poll

Twitter Poll (June 20, 2018)

ANSWER: D While the majority of cryoglobulinemic GNs do not show ultrastructural organization in deposits by EM, classically described deposits…

Vanessa Moreno, MD
By Vanessa Moreno, MD
Mixed cryoglobulinemia
Twitter Poll

Twitter Poll (April 4, 2018)

ANSWER: B Mixed cryoglobulinemia is most commonly caused by hepatitis C virus (HCV), with some cases caused by lymphoproliferative or…

By
Cryoglobulinemic Glomerulonephritis
Teaching Points

Hep C-Associated Cryoglobulinemic Glomerulonephritis

This biopsy was performed on a 66-year-old Caucasian male with a history of hepatitis C, who presented with nephrotic range…


cryoglobulinemia
Pushing Glass

Pushing Glass (January 12, 2018)

A 70-year-old female presents with 8 grams of proteinuria and a creatinine of 2.1. She relays that she has noticed…

Cryoglobulinemic Glomerulonephritis
L. Nich Cossey, MD
By L. Nich Cossey, MD
Cryoglobulinemic Intimal Arteritis
Teaching Points

Cryoglobulinemic Intimal Arteritis

This photomicrograph shows an artery with intimal edema and inflammation in a renal biopsy from a 56-year-old male with renal…


Cryoglobulinemic Deposits
Teaching Points

Cryoglobulinemic Deposits by EM

Electron microscopy can be helpful in the diagnosis of cryoglobulinemic glomerulonephritis. This renal biopsy (Fig. 1) shows a membranoproliferative pattern…

intimal arteritis
Diagnose This!

Diagnose This! (August 28, 2017)

What is this finding and what is the most likely etiology?   …

L. Nich Cossey, MD
By L. Nich Cossey, MD
Waldenstrom Macroglobulinemia
Teaching Points

Waldenstrom Macroglobulinemia

In this image of a combined silver-trichrome stain, the arrow points to the abnormal material within the arteriole lumen. This…