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KDIGO Connections

KDIGO Connections: HCV-Associated Kidney Disease

How do you treat patients with hepatitis C-associated kidney disease?

Type II Cryoglobulinemia
Twitter Poll

Twitter Post (August 30, 2018)

ANSWER: B Type II (mixed) cryoglobulinemia is characterized by immune-complexes containing a monoclonal Ig (usually IgM) that have an RF…

By Vanessa Moreno, MD
Mixed cryoglobulinemia
Twitter Poll

Twitter Poll (April 4, 2018)

ANSWER: B Mixed cryoglobulinemia is most commonly caused by hepatitis C virus (HCV), with some cases caused by lymphoproliferative or…

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Cryoglobulinemic Glomerulonephritis
Teaching Points

Hep C-Associated Cryoglobulinemic Glomerulonephritis

This biopsy was performed on a 66-year-old Caucasian male with a history of hepatitis C, who presented with nephrotic range…

Twitter Poll

Twitter Poll (November 30, 2017)

ANSWER: D Patients with HCV can present with membranoproliferative GN, Cryoglobulinemic GN, membranous GN, fibrillary GN, immunotactoid glomerulopathy and IgA…

By Vanessa Moreno, MD
Cryoglobulinemic Glomerulonephritis
By L. Nich Cossey, MD

Cryoglobulinemic Deposits
Teaching Points

Cryoglobulinemic Deposits by EM

Electron microscopy can be helpful in the diagnosis of cryoglobulinemic glomerulonephritis. This renal biopsy (Fig. 1) shows a membranoproliferative pattern…

Fibrillary Glomerulopathy
Teaching Points

Fibrillary Glomerulopathy

Commonly heard after we give the diagnosis: I heard about this in Fellowship This 62-year-old African-American just completed treatment for…

Patrick D. Walker, MD renal pathologist at arkana laboratories
By Patrick D. Walker, MD
calcineurin inhibitor toxicity
Pushing Glass

Pushing Glass (April 18, 2017)

A 45 year-old man received renal transplantation for HCV-associated end stage renal disease. He is currently treated with Sofobuvir, Tacrolimus…

By Dao-Fu Dai, MD