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Arkana Laboratories, renal pathology, Membranous Nephropathy
Teaching Points

Resolving Membranous Nephropathy

A 40-year-old white male presents with 3 grams/24 hr of proteinuria and swelling around his ankles. He reports that he…

Type 1 Cryoglobulinemic Glomerulonephritis, arkana laboratories
Teaching Points

Type 1 Cryoglobulinemic Glomerulonephritis

The patient is a 75 year-old female who presents with proteinuria, a necrotic skin lesion on her lower extremity, and…

KDIGO, Membranous Glomerulopathy, KDIGO Connections, renal pathology
KDIGO Connections

KDIGO Connections: Membranous Glomerulopathy

Welcome to the first post in our new series KDIGO Connections, a series in which we are asking our nephrologist…


Infection-Associated Glomerulonephritis in renal biopsy
Teaching Points

Infection-Associated Glomerulonephritis

This biopsy is taken from a 39-year-old woman who presents with abdominal pain, ascites, and lower extremity edema. Her serum…

type 1 cryoglobulinemia, renal biopsy, kidney disease, arkana laboratories, pushing glass
Pushing Glass

Pushing Glass (September 7, 2018)

The patient is a 75-year-old female who presents with proteinuria and a creatinine of 2.50. She has chronic lymphocytic leukemia,…

Monoclonal Gammopathy of Renal Significance
Diagnose This!

Diagnose This! (August 6, 2018)

What is your diagnosis? This is a complicated case. The photomicrographs show a membranoproliferative pattern glomerulonephritis (MPGN) with IgG Lambda…

By L. Nich Cossey, MD

severe mesangial matrix expansion with frequent large nodule formation, Diabetic Glomerulosclerosis
Teaching Points

Diabetic Glomerulosclerosis with Superimposed Diseases

Diabetic glomerulosclerosis is one of the most common causes of nephrotic range proteinuria in adults. When the clinical course of…

Membranous Glomerulopathy
Diagnose This!

Diagnose This (June 25, 2018)

What immunofluorescence stain is shown here, what is the immune complex deposition pattern and what disease does it represent? …

By L. Nich Cossey, MD
Teaching Points

Membranous with FSGS

Some patients with membranous glomerulopathy also have associated focal segmental glomerulosclerosis (FSGS) lesions. The glomerulus in this biopsy image, for…


Diagnose This!

Diagnose This (March 26, 2018)

In the setting of weak C3 (1-2+) only staining by routine immunofluorescence, what is your diagnosis? …

By L. Nich Cossey, MD
fibrillary glomerulopathy
By L. Nich Cossey, MD
Membranous Glomerulopathy
By L. Nich Cossey, MD

Vascular Staining in Membranous
Teaching Points

Vascular Staining in Membranous

This immunofluorescence (IF) image shows extensive granular glomerular capillary wall IgG deposits, consistent with membranous glomerulopathy. The glomerular staining pattern…

Immunotactoid Glomerulopathy
By L. Nich Cossey, MD
Fibrillary Glomerulopathy
Pushing Glass

Pushing Glass (August 8, 2017)

A 69-year-old man with past medical history of hypertension presents with nephrotic syndrome and 7 gm/day proteinuria. Serological studies are…

By Md Shahrier Amin, MD