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NCAM1, Membranous Nephropathy, Lipoic Acid in NELL1-Associated Membranous Nephropathy, SARS-CoV-2, biopsy, TGFBR3, crystalline nephropathies, Renal Intratubular Casts, viral-like inclusions, Covid-19, Anti-Brush Border Antibody Disease, MGMID, renal pathology, kidney research

A Diagnostician’s Field Guide To Crystalline Nephropathies

This discussion focuses on a review article of crystals seen in renal biopsies. Crystalline nephropathies are often associated with systemic…

By Dr. Rebecca May
Adenine phosphoribosyltransferase (APRT), Twitter Poll, Arkana Laboratories
Twitter Poll

Twitter Poll (February 5, 2020)

ANSWER: D, All of the Above 2,8-dihydroxyadeninuria (DHA) disease is a rare autosomal recessive disorder caused by complete adenine phosphoribosyltransferase…

By Vanessa Moreno, MD
Renal Oxalosis, arkana laboratories, renal pathology, kidney biopsy, Diagnose This
Diagnose This!

Diagnose This (July 1, 2019)

What is your diagnosis?   …

By L. Nich Cossey, MD

Renal oxalosis, arkana laboratories, teaching point at arkana Laboratories, renal pathology
Teaching Points

Renal Oxalosis

A 25-year-old female presents to the hospital with malaise and a creatinine of 3.5. She reports that she was in…

stained calcium deposits
Teaching Points

Bile Stained Calcium Oxalate Crystals

A renal biopsy was performed on this 75-year-old female who presented with acute liver failure, jaundice and acute renal failure…

2,8 DHA Crystalline Nephropathy
Teaching Points

2,8 DHA Crystalline Nephropathy

The renal biopsy shown here has crystals present within the tubular lumens and cytoplasm with a brownish appearance by H&E…

Teaching Points

Oxalate Due to Vitamin C

  A 51-year-old female with a history of SLE was found to have acute renal failure. There was no evidence…

Calcium Phosphate Deposits
Teaching Points

Calcium Phosphate Deposits

Calcium phosphate deposits Calcium phosphate deposits within the kidney may be seen in the setting of hypercalcemia/ hypercalciuria or hyperphosphatemia/…

adenine phosphoribosyltransferase
Diagnose This!

Diagnose This! (October 16, 2017)

What is your diagnosis?       The photomicrograph shows a distended tubule with an intratubular crystalline cast with argyrophilia.…

By L. Nich Cossey, MD

(2,8-DHA) 2,8-dihydroxyadenine
Teaching Points


Adenine phosphoribosyltransferase (APRT) deficiency results from an autosomal recessive enzyme defect of purine metabolism and leads to 2,8-dihydroxyadenine (2,8-DHA) crystalline…