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Diagnose This (January 17, 2022)
This is the albumin immunofluorescence stain from a biopsy from a patient with recent COVID pneumonia and nephrotic syndrome. What…
Art of Medicine: Covid-19 Associated Nephropathy (COVAN)
Development of acute kidney injury (AKI) in the setting of COVID-19 substantially worsens outcomes, with increased morbidity and mortality, and…
Another MYMP Sighting!
Another MYMP sighting! Durning our case conference today, Dr. Caza and Dr. Larsen discussed their recently published paper covering…
Twitter Poll (September 26, 2019)
ANSWER: C, Black APOL1-risk alleles have been reported only on African-derived chromosomes, including individuals from West Africa and recently admixed…
Art of Medicine: Collapsing Glomerulopathy
The above painting shows a glomerulus with capillary tuft collapse, visceral epithelial cell hyperplasia, and numerous protein resorption droplets within…
Art of Medicine: Lupus Nephritis Genetics
The above painting shows an image of a sequencing gel, which are produced by DNA synthesis in the presence of…
APOL1: Why Is It Important?
I have been working at Arkana Laboratories (formerly Nephropath) for close to seven years as the Molecular Diagnostics Laboratory Supervisor.…
Twitter Poll (April 17, 2019)
ANSWER: D Collapsing glomerulopathy has been associated with certain infectious disease including HIV, Hepatitis C, HTLV-1, parvovirus B19, cytomegalovirus, tuberculosis,…
Twitter Poll (March 21, 2018)
ANSWER: B AAPOAI Amyloidosis is the 2nd most common systemic hereditary amyloidosis which can be seen in kidney, liver, larynx,…
Collapsing Morphology
Collapsing glomerular lesions are aptly named, given the prominent collapse of glomerular tuft capillary loops. There is also hyperplasia and…
Microcystic Tubular Dilatation
Microcystic dilatation of tubules is a non-specific morphologic finding associated with various diseases, including obstructive nephropathy, HIV-associated nephropathy (HIVAN), congenital…
Collapsing Glomerulopathy
Collapsing glomerulopathy is characterized by glomerular tuft collapse with overlying epithelial hypertrophy and hyperplasia in Bowmans space. This pattern of…
Twitter Poll (October 4, 2017)
Answer: D Collapsing glomerulopathy has been associated with infection (HIV, parvovirus B19), drugs (INFs, BPs, CNIs) and APOL1-associated collapsing glomerulopathymutation…