Collapsing glomerulopathy is characterized by glomerular tuft collapse with overlying epithelial hypertrophy and hyperplasia in Bowman’s space. This pattern of glomerular injury is most commonly seen in African Americans and has been shown to be strongly associated with the presence of APOL1-mediated kidney disease risk variants in a number of associated diseases including HIV infection, lupus nephritis, interferon therapy, PLA2R-positive membranous glomerulopathy, and idiopathic cases.
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