Search & Filter All Posts
All Articles
(29 Results)
Monoclonal Membranous Glomerulopathy
Membranous glomerulopathy (MG) is a common cause of nephrotic syndrome that results from the formation of immune complexes along the…
Monoclonal Gammopathy of Renal Significance
The renal biopsy shown here has an MPGN pattern of injury by light microscopy. Routine immunofluorescence on the fresh (unfixed)…
Light Chain Deposition Disease
An elderly patient presents to nephrology for a rising creatinine. Baseline creatinine was 2.1 mg/dl six weeks prior but is…
Light Chain Proximal Tubulopathy Crystals
This image shows the prominent intracytoplasmic tubular epithelial crystals characteristic of a subset of light chain proximal tubulopathy cases associated…
Pushing Glass (August 22, 2017)
An 85-year-old gentleman presents to the clinic with nephrotic range proteinuria and a creatinine of 10.0 mg/dl. He reports a…
Pushing Glass (July 25, 2017)
The patient is a 64-year-old female who presents with 4.5 grams of proteinuria, hematuria, and a creatinine of 1.5. She…
Amyloid Casts
The differential diagnosis of acute renal failure in patients with multiple myeloma includes light chain cast nephropathy, amyloidosis, and monoclonal…
Light Chain Cast Nephropathy
Immunofluorescence staining with kappa light chain and lambda light chain antibodies shows negative kappa in casts that are lambda positive…
Waldenstrom Macroglobulinemia
In this image of a combined silver-trichrome stain, the arrow points to the abnormal material within the arteriole lumen. This…
Proliferative Glomerulonephritis with Monoclonal IgG Deposits
This 76-year-old white female developed nephrotic syndrome over about 3 months. She has proteinuria, 9 gm/24h and an elevated creatinine…
Proliferative Glomerulonephritis with Monoclonal IgG Deposits
The glomerulus pictured for light microscopy shows membranoproliferative changes with mesangial hypercellularity, GBM duplication, and endocapillary proliferation. There is light…
Cryoglobulinemic Glomerulonephritis
Figure 1: PAS-stained section showing a glomerulus with a membranoproliferative pattern of glomerular injury characterized by mesangial matrix expansion and…
Light Chain Cast Nephropathy
Atypical fractured cast that is pale on PAS stain is suggestive of light chain cast nephropathy (LCCN). Immunofluorescence examination for…