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Smoking-Related Glomerulopathy
A renal biopsy was performed on this 52-year-old male with a history of hypertension and heavy tobacco use, who is…
Diagnose This (July 23, 2018)
What is your diagnosis? The images show thickened tubular basement membranes on PAS stain and kappa restricted staining of the…
Nephronophthisis by ISH
Nephronophthisis is an autosomal recessive tubulointerstitial nephropathy that is a leading genetic etiology of end stage renal disease in children…
HIV-Related Kidney Disease: HIVAN
This biopsy is taken from a patient with HIV/AIDS who presented with an elevated serum creatinine and nephrotic range proteinuria.…
Diabetic Glomerulosclerosis with Superimposed Diseases
Diabetic glomerulosclerosis is one of the most common causes of nephrotic range proteinuria in adults. When the clinical course of…
Peritubular Giant Cells
When giant cells surround tubules This renal biopsy was taken from a young woman with elevated serum creatinine (4.3 mg/dL),…
Light Chain Deposition Disease
The immunofluorescence in cases of monoclonal immunoglobulin deposition disease is characterized by linear tubular basement membrane staining. In these cases,…
Diagnose This (June 25, 2018)
What immunofluorescence stain is shown here, what is the immune complex deposition pattern and what disease does it represent? …
Proliferative Glomerulonephritis with Monoclonal IgG Deposits
This renal biopsy from a 57-year-old male with acute renal failure, hematuria, and nephrotic-range proteinuria shows a proliferative glomerulonephritis (A)…
Focal Segmental Glomerulosclerosis (FSGS), Tip Variant
This biopsy was performed on a 9-year-old female with no significant past medical history, who presents with nephrotic syndrome. The…
Twitter Poll (June 13, 2018)
ANSWER: C In patients older than 60 y/o, MGN is associated with malignancy in 20-30% of cases. The lung is…
Light Chain Proximal Tubulopathy Without Crystals Tutorial
The two most common morphologic variants of light chain proximal tubulopathy (LCPT) are LCPT with and without crystal formation. The…
Twitter Poll (June 6, 2018)
ANSWER: B Hodgkin lymphoma and less often other lymphoproliferative disorders have been associated in the pathogenesis of minimal change disease…
PLA2R Tutorial
The diagnosis of membranous glomerulopathy has been transformed in the past 10 years with the discovery of PLA2R. PLA2R is…