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AL Amyloidosis
Teaching Points

Vascular-Limited AL Amyloidosis

A renal biopsy was performed on this 78 year old male with history of diabetes mellitus, hypertension and monoclonal gammopathy…

DNAJB9, FGN, biomarker, kidney biopsy
Twitter Poll

Twitter Poll (May 2, 2018)

ANSWER: DNAJB9 DnaJ homolog subfamily B member 9 (DNAJB9) is a novel proteomic tissue biomarker for Fibrillary glomerulonephritis (FGN) that…

By Vanessa Moreno, MD
LECT2 Amyloidosis, tubulointerstitial and vascular deposition of a PAS-pale
Teaching Points

LECT2 Amyloidosis

The renal biopsy from this 79-year-old Hispanic male shows extensive glomerular, tubulointerstitial and vascular deposition of a PAS-pale (Fig 1),…


Fabry disease
By L. Nich Cossey, MD
Focal segmental glomerulosclerosis (FSGS)
Teaching Points

FSGS Types

The 3 main FSGS Types Are there clues to help distinguish among primary, genetic, and secondary focal segmental glomerulosclerosis (FSGS)…

secondary focal segmental glomerulosclerosis
Diagnose This!

Diagnose This (April 16, 2018)

The immunofluorescence study is negative. What is your diagnosis? …

By L. Nich Cossey, MD

Sickle Cell Nephropathy
Twitter Poll

Twitter Poll (March 28, 2018)

ANSWER: D Some of the histologic features observed in Sickle Cell Nephropathy that involve the glomerular compartment are: enlarged glomeruli…

By Vanessa Moreno, MD
jones stain, masked IgG kappa deposits
Teaching Points

Membranous-Like Glomerulopathy with Masked IgG-Kappa Deposits

Immunoglobulin deposits identified on renal biopsy samples by paraffin immunofluorescence that show negative staining by routine immunofluorescence on frozen tissue…

persistent proteinuria, membranous glomerulopathy
Teaching Points

Resolving Membranous Glomerulopathy

A renal biopsy was performed on this 55-year-old female with a history of biopsy-proven membranous glomerulopathy status post immunosuppressive therapy,…


Diagnose This!

Diagnose This (March 26, 2018)

In the setting of weak C3 (1-2+) only staining by routine immunofluorescence, what is your diagnosis? …

By L. Nich Cossey, MD
A-galactosidase A , pushing glass, arkana laboratories, kidney disease
Pushing Glass

Pushing Glass (March 23, 2018)

These images are from the kidney biopsy of a 70-year-old woman with a history of hypertension and valvular heart disease…

By Md Shahrier Amin, MD
AAPOAI Amyloidosis
Twitter Poll

Twitter Poll (March 21, 2018)

ANSWER: B AAPOAI Amyloidosis is the 2nd most common systemic hereditary amyloidosis which can be seen in kidney, liver, larynx,…

By Vanessa Moreno, MD

glomerulus with Congo red positive mesangial staining
Teaching Points

Congo Red Stain Tutorial

Congo Red Stain Tutorial: What does it show? Positive Congo red staining in tissue with apple-greenbirefringenceunderpolarized lightis diagnostic of the…

Collapsing glomerular lesions
Teaching Points

Collapsing Morphology

Collapsing glomerular lesions are aptly named, given the prominent collapse of glomerular tuft capillary loops. There is also hyperplasia and…

ANCA Disease, LECT2 Amyloid, IgG4-Related Disease, AL amyloidosis, ANCA, digging deeper, Dr. Messias, Arkana Laboratories, pathology diseases
Digging Deeper

When Lightning Strikes Twice

This biopsy came to us for a workup on proteinuria. The patient is a 68-year-old female with a history of…

By Nidia Messias, MD