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Tuberculosis, caseating necrosis in the renal parenchyma
Teaching Points

Tuberculosis – AFB and Rhodamine

A 69-year-old Caucasian man presented with general malaise and multiple febrile episodes that started several weeks prior to presentation. He…

Jones stain, jones depositis, arkana laboratories, renal biopsy, kidney biopsies
Teaching Points

Jones Deposits

A well-prepared Jones methenamine silver stain can help localize immune deposits. By sharply defining the glomerular capillary basement membrane (GBM),…

PAS-pale, focally fractured tubular casts with associated cellular reaction
Teaching Points

Light Chain Cast Nephropathy with Congo Red Staining

This biopsy was taken from a 60-year-old African American female with a history of diabetes mellitus and hypertension, who presented…


IgA, IgA Differential, IgA nephropathy
Teaching Points

IgA Differential

IgA nephropathy is defined by IgA dominant or co-dominant deposits in glomeruli in the absence of systemic disease. Other diseases…

Robots at arkana laboratories helping with staining for kidney biopsy
Teaching Points

Lab Robots

Friendly robots help anatomic pathology laboratories maintain high quality and efficiency! Laboratories began introducing automation technology on a large scale…

LECT2 Amyloidosis, tubulointerstitial and vascular deposition of a PAS-pale
Teaching Points

LECT2 Amyloidosis

The renal biopsy from this 79-year-old Hispanic male shows extensive glomerular, tubulointerstitial and vascular deposition of a PAS-pale (Fig 1),…


fibrosis, Chronic interstitial nephritis, CIN
Teaching Points

CIN Due To PPI

Chronic interstitial nephritis (CIN) is diagnosed when interstitial inflammation is present in areas of fibrosis (A) in combination with the…

Focal segmental glomerulosclerosis (FSGS)
Teaching Points

FSGS Types

The 3 main FSGS Types Are there clues to help distinguish among primary, genetic, and secondary focal segmental glomerulosclerosis (FSGS)…

Teaching Points

Oxalate Due to Vitamin C

  A 51-year-old female with a history of SLE was found to have acute renal failure. There was no evidence…


Vascular Resistance
Teaching Points

Vascular Resistance

The sampled artery in this kidney biopsy shows severe arteriosclerosis. The deleterious effects of a narrowed arterial lumen and increased…

Nephrocalcinosis in Sarcoid, renal cortex
Teaching Points

Nephrocalcinosis in Sarcoid

The renal biopsy in these photomicrographs shows tubular injury with increased interstitial calcium phosphate deposition. Focal interstitial calcium phosphate can…

Interstitial Hemorrhage in renal cortex
Teaching Points

Interstitial Hemorrhage

The differential diagnosis for interstitial hemorrhage includes hemorrhagic necrosis in the setting of renal artery thrombosis, infection (e.g. herpes simplex…


necrotizing lesions, glomeruli, large subendothelial immune deposits
Teaching Points

Immune Deposits in SLE

The ISN/RPS 2004 classification of lupus nephritis is entirely based on glomerular changes. Depending on the presence or absence of…

jones stain, masked IgG kappa deposits
Teaching Points

Membranous-Like Glomerulopathy with Masked IgG-Kappa Deposits

Immunoglobulin deposits identified on renal biopsy samples by paraffin immunofluorescence that show negative staining by routine immunofluorescence on frozen tissue…

Chronic Active T Cell-Mediated Rejection, renal cortex
Teaching Points

Chronic Active T Cell-Mediated Rejection

Chronic active T cell-mediated rejection (TCMR) was included in the 2017 Banff classification system for the evaluation of kidney allografts…