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Light Chain Proximal Tubulopathy with Crystals
The two most common morphologic variants of light chain proximal tubulopathy (LCPT) are LCPT with and without crystal formation. The…
Twitter Poll (January 24, 2018)
ANSWER: C Patients with rhabdomyolysis present with acute tubular injury with pigmented casts (myoglobin casts) positive for myoglobin
Amyloid Cast Nephropathy
Cases of light chain cast nephropathy occasionally show amyloid staining properties including positive staining for Congo red with green birefringence…
Fibrinogen Aα-chain Amyloidosis
A 65-year-old male, with no significant past medical history, presents with proteinuria and worsening renal function. The serum creatinine is…
Pushing Glass (January 12, 2018)
A 70-year-old female presents with 8 grams of proteinuria and a creatinine of 2.1. She relays that she has noticed…
Twitter Poll (January 11, 2018)
ANSWER D: Tubulopathy with isometric vacuolization, acute tubular injury, acute arteriolopathy and TMA can be seen in acute CNIT.
Twitter Poll (January 4, 2018)
ANSWER: D Endocapillary hypercellularity, crescents, karyorrhexis and wire loops are some of the glomerular lesions seen in lupus nephritis class…
Crescentic Glomerulonephritis with IgA Deposits
This biopsy was taken from a 58-year-old male with no significant past medical history, who presents with gross hematuria, serum…
Cholesterol Microemboli
Cholesterol emboli involving the kidney may manifest clinically as acute kidney injury, hematuria, proteinuria (both non-nephrotic and nephrotic range), and…
Malignant Hypertension
This renal biopsy shown here is from a 25-year-old male who presented with acute kidney injury in the setting of…
Twitter Poll (December 6, 2017)
ANSWER: A Dual positivity for MPO and PR3 antibodies is a strong clue for levamisole/cocaine DAV.
Infection-Associated GN
This kidney biopsy was performed on a 63-year-old female with a history of hypertension, congestive heart failure, lower extremity edema…
Collapsing Glomerulopathy
Collapsing glomerulopathy is characterized by glomerular tuft collapse with overlying epithelial hypertrophy and hyperplasia in Bowmans space. This pattern of…
IgA with Crescents, MEST-C
This biopsy is from a young adult patient with IgA nephropathy (the immunofluorescence image in Fig. 2 shows 2+ mesangial…