Back to Blog

Renal Vein Obstruction

Alejandro Best, MD renal pathologist at arkana laboratories
By Alejandro Best, MD

Nov 21, 2017

renal vein thrombosis

This biopsy is from a 60-year-old female, status post renal transplant 5 days prior, who was found to have mechanical obstruction of the renal vein during the surgical revision of the transplanted kidney, without evidence of thrombosis. The biopsy shows marked congestion of the glomerular capillary loops (Fig 1), peritubular capillaries and arterioles, along with margination of neutrophils (Fig 2), interstitial hemorrhage and severe acute tubular injury. C4d is negative and there are no other clinical or morphologic findings suspicious for hyperacute or acute antibody-mediated rejection. Renal vein or artery obstruction is a rare complication of renal transplantation which is usually secondary to thrombosis, especially in the setting of a hypercoagulable state or technical problems with the anastomoses. While no thrombosis was seen in this case, the morphologic findings are similar to those described in the setting of renal vein thrombosis.

margination of neutrophils, renal vein thrombosis


Quick note: This post is to be used for informational purposes only and does not constitute medical or health advice. Each person should consult their own doctor with respect to matters referenced. Arkana Laboratories assumes no liability for actions taken in reliance upon the information contained herein.