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Ask-Upmark, normal renal biopsy, arkana laboratories
Teaching Points

Ask-Upmark

This kidney biopsy is from a 16-year-old boy with a history of chronic reflux nephropathy. Imaging findings showed unilateral segmental…

Collagenofibrotic Glomerulopathy
Diagnose This!

Diagnose This! (February 12, 2018)

What is your diagnosis? (Congo red is negative as is routine immunofluorescence)   …

L. Nich Cossey, MD
By L. Nich Cossey, MD
extensive mesangial and subendothelial deposition of PAS-positive
Teaching Points

Fibronectin Glomerulopathy

A renal biopsy was performed in a 32-year-old female with microscopic hematuria and nephrotic range proteinuria of 4 grams per…


vacuolated cytoplasm, Fabry Disease in Female Carriers
Teaching Points

Fabry Disease in Female Carriers

A renal biopsy was performed on a 51-year-old female with strong family history of Fabry disease and a known carrier…

Amyloid Cast Nephropathy
Teaching Points

Amyloid Cast Nephropathy

Cases of light chain cast nephropathy occasionally show amyloid staining properties including positive staining for Congo red with green birefringence…

Fibrinogen Aα-chain Amyloidosis
Teaching Points

Fibrinogen Aα-chain Amyloidosis

A 65-year-old male, with no significant past medical history, presents with proteinuria and worsening renal function. The serum creatinine is…


Apolipoprotein A-IV Amyloidosis
Teaching Points

Apolipoprotein A-IV Amyloidosis

This renal biopsy from a 71-year-old female, who presented with progressively worsening renal failure, shows unremarkable glomeruli by light microscopy…

Embryonal Hyperplasia of Bowman's Capsule Epithelium
Teaching Points

Embryonal Hyperplasia of Bowman’s Capsule Epithelium

H&E and PAS-stained sections from the kidney of an 8-year-old male with advanced nephrosclerosis of unknown etiology. An exuberant proliferation…

Sclerosing Peritubular Nodule
Teaching Points

Sclerosing Peritubular Nodule

Todays teaching point is a true zebra in renal pathology. The arrows in the light microscopic image identify what have…