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Glomerular Basement Membrane

Glomerular Basement Membrane Duplication

This eyeSCANdy acellular scanning EM image of a glomerular basement membrane shows duplication in a biopsy with membranoproliferative pattern of…

Membranoproliferative Pattern, eyescandy, stephen Bonsib, Arkana Laboratories, renal pathology

Glomerulus with a Membranoproliferative Pattern

This eyeSCANdy image shows acellular scanning EM showing glomerular basement membrane duplication at high power in a glomerulus with a…

mesangiolysis, renal pathology, kidney biopsy stain, arkana laboratories
Diagnose This!

Diagnose This (August 5, 2019)

What is this finding in this native kidney? …

By L. Nich Cossey, MD

KDIGO Connections

KDIGO Connections: HCV-Associated Kidney Disease

How do you treat patients with hepatitis C-associated kidney disease?

Sickle Cell Nephropathy
Twitter Poll

Twitter Poll (March 28, 2018)

ANSWER: D Some of the histologic features observed in Sickle Cell Nephropathy that involve the glomerular compartment are: enlarged glomeruli…

By Vanessa Moreno, MD
ANCA Disease, LECT2 Amyloid, IgG4-Related Disease, AL amyloidosis, ANCA, digging deeper, Dr. Messias, Arkana Laboratories, pathology diseases
Digging Deeper

When Lightning Strikes Twice

This biopsy came to us for a workup on proteinuria. The patient is a 68-year-old female with a history of…

By Nidia Messias, MD

intravascular diffuse large B-cell lymphoma, arkana laboratories, pushing glass, renal pathology
Pushing Glass

Pushing Glass (March 13, 2018)

A 65-year-old male presents with mild proteinuria and a sudden increase in creatinine. He was recently diagnosed with widely metastatic…

Membranoproliferative Glomerulonephritis
Teaching Points

Membranoproliferative Glomerulonephritis Pattern

This glomerulus shows a membranoproliferative glomerulonephritis (MPGN) pattern of injury. To a large extent, the etiologic differential diagnosis depends on…

Cryoglobulinemic Glomerulonephritis
Teaching Points

Hep C-Associated Cryoglobulinemic Glomerulonephritis

This biopsy was performed on a 66-year-old Caucasian male with a history of hepatitis C, who presented with nephrotic range…

Monoclonal Gammopathy
Teaching Points

Monoclonal Gammopathy of Renal Significance

The renal biopsy shown here has an MPGN pattern of injury by light microscopy. Routine immunofluorescence on the fresh (unfixed)…

Lymphocytic Leukemia (CLL and SLL)
Teaching Points

Lymphocytic Leukemia (CLL and SLL)

This renal biopsy was taken from an 82-year-old man with acute renal failure and nephrotic range proteinuria. His past medical…

Proliferative Glomerulonephritis with Monoclonal IgG Deposits
Teaching Points

Proliferative Glomerulonephritis with Monoclonal IgG Deposits

The glomerulus pictured for light microscopy shows membranoproliferative changes with mesangial hypercellularity, GBM duplication, and endocapillary proliferation. There is light…

Cryoglobulinemic Glomerulonephritis
Teaching Points

Cryoglobulinemic Glomerulonephritis

Figure 1: PAS-stained section showing a glomerulus with a membranoproliferative pattern of glomerular injury characterized by mesangial matrix expansion and…

Cryoglobulinemic glomerulonephritis
Pushing Glass

Pushing Glass (March 22, 2017)

A 71-year-old woman with a history of multiple myeloma, hypertension and vitamin D deficiency presented with decreased renal function. Investigations…

By Md Shahrier Amin, MD