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Glomerular Basement Membrane Duplication
This eyeSCANdy acellular scanning EM image of a glomerular basement membrane shows duplication in a biopsy with membranoproliferative pattern of…
Glomerulus with a Membranoproliferative Pattern
This eyeSCANdy image shows acellular scanning EM showing glomerular basement membrane duplication at high power in a glomerulus with a…
KDIGO Connections: HCV-Associated Kidney Disease
How do you treat patients with hepatitis C-associated kidney disease?
Twitter Poll (March 28, 2018)
ANSWER: D Some of the histologic features observed in Sickle Cell Nephropathy that involve the glomerular compartment are: enlarged glomeruli…
When Lightning Strikes Twice
This biopsy came to us for a workup on proteinuria. The patient is a 68-year-old female with a history of…
Pushing Glass (March 13, 2018)
A 65-year-old male presents with mild proteinuria and a sudden increase in creatinine. He was recently diagnosed with widely metastatic…
Membranoproliferative Glomerulonephritis Pattern
This glomerulus shows a membranoproliferative glomerulonephritis (MPGN) pattern of injury. To a large extent, the etiologic differential diagnosis depends on…
Hep C-Associated Cryoglobulinemic Glomerulonephritis
This biopsy was performed on a 66-year-old Caucasian male with a history of hepatitis C, who presented with nephrotic range…
Monoclonal Gammopathy of Renal Significance
The renal biopsy shown here has an MPGN pattern of injury by light microscopy. Routine immunofluorescence on the fresh (unfixed)…
Lymphocytic Leukemia (CLL and SLL)
This renal biopsy was taken from an 82-year-old man with acute renal failure and nephrotic range proteinuria. His past medical…
Proliferative Glomerulonephritis with Monoclonal IgG Deposits
The glomerulus pictured for light microscopy shows membranoproliferative changes with mesangial hypercellularity, GBM duplication, and endocapillary proliferation. There is light…
Cryoglobulinemic Glomerulonephritis
Figure 1: PAS-stained section showing a glomerulus with a membranoproliferative pattern of glomerular injury characterized by mesangial matrix expansion and…
Pushing Glass (March 22, 2017)
A 71-year-old woman with a history of multiple myeloma, hypertension and vitamin D deficiency presented with decreased renal function. Investigations…
