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(25 Results)Introduction to Systemic Lupus Erythematosus and Clinical Diagnostic Criteria
Systemic lupus erythematosus (SLE) Systemic lupus erythematosus (SLE) is a systemic autoimmune disease which affects over 5 million people worldwide,…
Twitter Poll (February 27, 2019)
Answer: B “Endocapillary hypercellularity” is the new term recommended to be used instead of “endocapillary proliferation”. This is a more…
Lupus Nephritis (Class IV)
A 20-year-old female presents with hematuria, proteinuria, and a creatinine of 1.2 mg/dl. Serologies for ANA are positive. Complement levels…
Twitter Poll (June 28, 2018)
ANSWER: A This is true. In contrast, a diagnosis of combined class IV and class V lupus nephritis is warranted…
Immune Deposits in SLE
The ISN/RPS 2004 classification of lupus nephritis is entirely based on glomerular changes. Depending on the presence or absence of…
Twitter Poll (January 4, 2018)
ANSWER: D Endocapillary hypercellularity, crescents, karyorrhexis and wire loops are some of the glomerular lesions seen in lupus nephritis class…
Subepithelial Deposits in Lupus Nephritis
According to the ISN/RPS 2003 classification of lupus nephritis, membranous lupus nephritis (class V) is characterized by the presence…
Tissue Antinuclear Antibodies
This immunofluorescence image (anti-IgG) shows prominent tissue ANA in a patient with lupus nephritis. Normally, the nuclei in renal tissues…
Class III Focal Lupus Nephritis
This 9-year-old female was recently evaluated for lymphoid malignancy due to weight loss and intermittent fevers. Following a negative workup…