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Systemic Lupus Erythematosus, SLE, lupus nephritis, arkana laboratories, disease week, renal pathology
Disease Week

Introduction to Systemic Lupus Erythematosus and Clinical Diagnostic Criteria

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease which affects over 5 million people worldwide, and manifests as tissue…

Endocapillary hypercellularity, arkana laboratories, twitter poll
Twitter Poll

Twitter Poll (February 27, 2019)

Answer: B “Endocapillary hypercellularity” is the new term recommended to be used instead of “endocapillary proliferation”. This is a more…

Vanessa Moreno, MD
By Vanessa Moreno, MD
Lupus Nephritis, arkana laboratories, teaching point, nephropathology
Teaching Points

Lupus Nephritis (Class IV)

A 20-year-old female presents with hematuria, proteinuria, and a creatinine of 1.2 mg/dl. Serologies for ANA are positive. Complement levels…


Subepithelial Deposits
Twitter Poll

Twitter Poll (June 28, 2018)

ANSWER: A This is true. In contrast, a diagnosis of combined class IV and class V lupus nephritis is warranted…

Vanessa Moreno, MD
By Vanessa Moreno, MD
necrotizing lesions, glomeruli, large subendothelial immune deposits
Teaching Points

Immune Deposits in SLE

The ISN/RPS 2004 classification of lupus nephritis is entirely based on glomerular changes. Depending on the presence or absence of…

Lupus Nephritis Class III/IV
Twitter Poll

Twitter Poll (January 4, 2018)

ANSWER: D Endocapillary hypercellularity, crescents, karyorrhexis and wire loops are some of the glomerular lesions seen in lupus nephritis class…

Vanessa Moreno, MD
By Vanessa Moreno, MD

Subepithelial Deposits in Lupus Nephritis
Teaching Points

Subepithelial Deposits in Lupus Nephritis

According to the ISN/RPS 2003 classification of lupus nephritis, membranous lupus nephritis (class V) is characterized by the presence of…

Tissue Antinuclear Antibodies
Teaching Points

Tissue Antinuclear Antibodies

This immunofluorescence image (anti-IgG) shows prominent tissue ANA in a patient with lupus nephritis. Normally, the nuclei in renal tissues…

Lupus Nephritis ISN/RPS Class V
L. Nich Cossey, MD
By L. Nich Cossey, MD

Focal Lupus Nephritis, mesangial hypercellularity
Teaching Points

Class III Focal Lupus Nephritis

This 9-year-old female was recently evaluated for lymphoid malignancy due to weight loss and intermittent fevers. Following a negative workup…

Patrick D. Walker, MD renal pathologist at arkana laboratories
By Patrick D. Walker, MD