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How “omnioma” virus became “polyoma” virus…
The arrow points to an intranuclear viral inclusion characteristic of BK virus, one species of non-enveloped dsDNA viruses belonging to…
Cystinosis
Cystinosis is an autosomal recessive lysosomal storage disease caused by CTNS gene mutations. The normal product of the CTNS gene…
Polyomavirus Nephropathy in Native Kidney
Polyomavirus nephropathy (PVN), predominantly caused by BK virus reactivation in the urogenital tract, is an important complication of renal allografts…
A source of myoglobinuria…
The image shows a frozen cross section of skeletal muscle from a patient with rhabdomyolysis, which included the full clinical…
Fungus Microabscess
Cortical microabscess formation is a clue to the presence of an infectious organism. Various bacteria, viruses, fungi, and even parasites…
DNAJB9 helps uncover dual pathology…
This case illustrates the utility of immunohistochemical staining for DNAJB9, a recently described biomarker for fibrillary glomerulopathy (see reference). The…
Membranous Glomerulopathy in Obesity-Related Glomerulopathy
The patient is a 57-year-old female, with a history of morbid obesity and persistent mild proteinuria (approximately 1 gm), who…
An Incidental Finding…
An incidental finding in this kidney biopsy was the presence of granular black deposits along glomerular capillary walls and within…
Differential Diagnosis of Kidney Injury in CLL/SLL Patients
There are many causes of decreased kidney function in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), and a renal…
Proliferative Glomerulonephritis with Monoclonal IgG Deposits
This biopsy was performed on a 58-year-old female who presented with mild proteinuria. The glomeruli show diffuse and global endocapillary…
Malpighi Glomerulus
How long have we known about glomeruli? Todays teaching point is offered in honor of Marcello Malpighi (1628-1694), the Italian…
Interstitial Foam Cells
This 52-year-old female underwent a renal biopsy as part of the workup for nephrotic syndrome. The biopsy is diagnostic for…
Thyroidization
One of the many patterns of tubular atrophy in the kidney is the aptly named thyroidization pattern because of its…
Renal Arterial Thromboemboli
Infective endocarditis can have numerous deleterious effects on the kidney. One such renal complication is the formation of arterial thromboemboli.…
Endocapillary Hypercellularity in Thrombotic Microangiopathy
This renal biopsy performed on a 14-year-old boy shows changes diagnostic of a thrombotic microangiopathy (TMA). These changes include frequent…