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Adenovirus
This allograft biopsy shows the characteristic features of adenovirus infection. There is prominent interstitial hemorrhage and edema (Fig. 1), acute…
A Case of an Unlucky Strike
This biopsy was from a 57-year-old African American female patient. She presented with a gradual increase in serum creatinine over…
Giant Cells
Sometimes the giant cells in granulomatous inflammation are truly giant!
Chronic Active Antibody-Mediated Rejection
A diagnosis of chronic active antibody-mediated rejection (ABMR) requires morphologic evidence of chronic tissue injury (e.g. transplant glomerulopathy), evidence of…
Tuberculosis – AFB and Rhodamine
A 69-year-old Caucasian man presented with general malaise and multiple febrile episodes that started several weeks prior to presentation. He…
Light Chain Cast Nephropathy with Congo Red Staining
This biopsy was taken from a 60-year-old African American female with a history of diabetes mellitus and hypertension, who presented…
Twitter Poll (April 25, 2018)
ANSWER: C Mild to moderate intimal arteritis (v1), with or without interstitial inflammation and/or tubulitis is considered as acute TCMR…
IgA Differential
IgA nephropathy is defined by IgA dominant or co-dominant deposits in glomeruli in the absence of systemic disease. Other diseases…
Twitter Poll (April 18, 2018)
ANSWER: C Shiga toxin-producing E. coli is one of the most common pathogens involved in foodborne disease outbreak linked to…
Oxalate Due to Vitamin C
A 51-year-old female with a history of SLE was found to have acute renal failure. There was no evidence…
Twitter Poll (April 11, 2018)
ANSWER: B The criteria for acute T-cell mediated rejection Banff grade IB includes interstitial inflammation involving >25% of non-sclerotic cortical…
Interstitial Hemorrhage
The differential diagnosis for interstitial hemorrhage includes hemorrhagic necrosis in the setting of renal artery thrombosis, infection (e.g. herpes simplex…
Immune Deposits in SLE
The ISN/RPS 2004 classification of lupus nephritis is entirely based on glomerular changes. Depending on the presence or absence of…