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Infection-Associated Glomerulonephritis
Diagnose This!

Diagnose This (April 2, 2018)

What is the most likely diagnosis? …

By L. Nich Cossey, MD
Interstitial Eosinophils
Teaching Points

Interstitial Eosinophils

Prominent interstitial eosinophils (see arrow) are most often associated with allergic-type acute interstitial nephritis (AIN). However, interstitial eosinophils are not…

mild endocapillary hypercellularity with rare double contour formation of the capillary loops, Proliferative Glomerulonephritis with Monoclonal IgG Deposits
Teaching Points

Proliferative Glomerulonephritis with Monoclonal IgG Deposits

This biopsy was performed on an 81-year-male, status post renal transplant, who presented with increased creatinine (2.3 mg/dl) and microscopic…


intravascular diffuse large B-cell lymphoma, arkana laboratories, pushing glass, renal pathology
Pushing Glass

Pushing Glass (March 13, 2018)

A 65-year-old male presents with mild proteinuria and a sudden increase in creatinine. He was recently diagnosed with widely metastatic…

pregnancy related kidney disease, pregnancy
Twitter Poll

Twitter Poll (March 8, 2018)

ANSWER: A True! Pregnancy related complications increase the risk of kidney disease.

By Vanessa Moreno, MD
Tubular Cast Tutorial
Teaching Points

Tubular Cast Tutorial

There is a histopathologic spectrum to the casts that can be seen in light chain cast nephropathy. A portion of…


Intimal Arteritis
Twitter Poll

Twitter Poll (February 28, 2018)

ANSWER: C Intimal arteritis (v1 and v2) is more commonly associated with mixed ABMR/TCMR than with pure ABMR. It may…

By Vanessa Moreno, MD
BK Nephritis with Nuclear Inclusions in a Transplant on H&E
Diagnose This!

Diagnose This! (February 26, 2018)

What is your diagnosis of this renal transplant patient? …

By L. Nich Cossey, MD
ANCA-Associated GN
Twitter Poll

Twitter Poll (February 21, 2018)

ANSWER: D ANCA-associated GN and anti-GBM GN are the most common causes of pulmonary-renal syndrome accounting for about 90% of…

By Vanessa Moreno, MD

Acute Pyelonephritis
Teaching Points

Acute Pyelonephritis in Transplants

Acute pyelonephritis in transplant settings (allograft pyelonephritis) is a known cause of allograft dysfunction and a complication that occurs in…

Granulomatous Interstitial Nephritis, renal biopsy, renal cortex
Teaching Points

Granulomatous Interstitial Nephritis Differential

This biopsy is from a 25-year-old African American female with renal failure. The photomicrographs here show renal involvement by non-caseating…

Papillary Necrosis
Teaching Points

Papillary Necrosis

This kidney biopsy is from an elderly adult patient with acute renal failure and a history of non-steroidal anti-inflammatory medication…


Approximately 25-30% of the patients with anti-GBM crescentic glomerulonephritis are ANCA positive
Twitter Poll

Twitter Poll (February 1, 2018)

ANSWER: C Approximately 25-30% of the patients with anti-GBM crescentic glomerulonephritis are ANCA positive, usually for MPO-ANCA.

By Vanessa Moreno, MD
Thrombotic Microangiopathy
Diagnose This!

Diagnose This! (January 29, 2018)

What is your diagnosis? Immunofluorescence is negative.   …

By L. Nich Cossey, MD
Pushing Glass

Pushing Glass (January 26, 2018)

An otherwise asymptomatic 65-year-old man presents for medical evaluation after 15 years of not seeing a physician. He was noted…

By Md Shahrier Amin, MD