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Resolving Membranous Glomerulopathy
A renal biopsy was performed on this 55-year-old female with a history of biopsy-proven membranous glomerulopathy status post immunosuppressive therapy,…
Congo Red Stain Tutorial
Congo Red Stain Tutorial: What does it show? Positive Congo red staining in tissue with apple-greenbirefringenceunderpolarized lightis diagnostic of the…
Collapsing Morphology
Collapsing glomerular lesions are aptly named, given the prominent collapse of glomerular tuft capillary loops. There is also hyperplasia and…
Subepithelial Humps
The depicted electron micrograph shows numerous, large and irregular subepithelial deposits which protrude from the glomerular basement membrane towards…
Potential Diagnostic Pitfall of PIF Method
The paraffin immunofluorescence technique is simple to perform for renal pathology laboratories familiar with routine IF. It is important as…
Interstitial Eosinophils
Prominent interstitial eosinophils (see arrow) are most often associated with allergic-type acute interstitial nephritis (AIN). However, interstitial eosinophils are not…
Proliferative Glomerulonephritis with Monoclonal IgG Deposits
This biopsy was performed on an 81-year-male, status post renal transplant, who presented with increased creatinine (2.3 mg/dl) and microscopic…
Tubular Cast Tutorial
There is a histopathologic spectrum to the casts that can be seen in light chain cast nephropathy. A portion of…
Membranoproliferative Glomerulonephritis Pattern
This glomerulus shows a membranoproliferative glomerulonephritis (MPGN) pattern of injury. To a large extent, the etiologic differential diagnosis depends on…
Chronic Uric Acid Nephropathy
Chronic uric acid nephropathy results from deposition within the renal parenchyma of monosodium urate monohydrate. While the disease may occur…
Light Chain Proximal Tubulopathy Amyloid Proximal Tubulopathy Type
The two most common morphologic variants of light chain proximal tubulopathy (LCPT) are LCPT with and without crystal formation. Two…
Microcystic Tubular Dilatation
Microcystic dilatation of tubules is a non-specific morphologic finding associated with various diseases, including obstructive nephropathy, HIV-associated nephropathy (HIVAN), congenital…
Ask-Upmark
This kidney biopsy is from a 16-year-old boy with a history of chronic reflux nephropathy. Imaging findings showed unilateral segmental…
Hep C-Associated Cryoglobulinemic Glomerulonephritis
This biopsy was performed on a 66-year-old Caucasian male with a history of hepatitis C, who presented with nephrotic range…
Alport IF
In patients suspected of having Alport syndrome, immunofluorescence staining can be used to detect abnormal expression of various alpha chains…