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Myopathy in Acute Lymphoma
Clinical History This 77-year-old patient presented with atrophy of the cranial and extremity muscles, dysphagia, and multiple falls. Past medical…
Amyloid C5b-9
Clinical History: This 64-year-old patient presents with progressive distal bilateral upper and lower extremity numbness and pain. They also reported…
Hereditary Amyloid Neuropathy
Elderly female with amyloid neuropathy of the sural nerve. Cross-sections of the left sural nerve prepared from formalin-fixed paraffin-embedded (FFPE)…
Diagnose This (August 2, 2021)
This biopsy is from a 61yo male with DM, CHF, CKD4, and an abnormal SPEP. UMOD IHC was negative. What…
ALECT2 Amyloidosis
The patient is a 75-year-old Hispanic male who presents with progressively worsening kidney function and a creatinine of 1.6 mg/dl…
Step By Step
The biopsy is from a 65 year-old female who presented with acute renal failure and elevated creatinine up to 1.9…
IgA nephropathy with something extra…
The biopsy is from a 61-year-old man with a history of intermittent microscopic hematuria for many years who presents with…
Pushing Glass (April 6, 2018)
A 75-year-old Hispanic male presents with a creatinine of 3. His creatinine has slowly been creeping up over the last…
Twitter Poll (March 21, 2018)
ANSWER: B AAPOAI Amyloidosis is the 2nd most common systemic hereditary amyloidosis which can be seen in kidney, liver, larynx,…
Twitter Poll (September 12, 2017)
Answer: C Amyloid fibrils typically measure 8-12 nm (answer C). The deposits seen in Immunotactoid glomerulopathy are composed by tubules…
AA Amyloid
This biopsy from a patient with massive proteinuria showed diffuse and near-global involvement of glomeruli by amorphous deposits (Fig. 1)…
Pushing Glass (July 25, 2017)
The patient is a 64-year-old female who presents with 4.5 grams of proteinuria, hematuria, and a creatinine of 1.5. She…
Congo Red Stain
Importance of the congo red stain The ability to detect amyloid deposits in human tissue is the critical first step…
LECT2
Photomicrographs show extensive interstitial and glomerular deposition of Congo red positive material that stains positive for LECT2. Despite being one…
