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A Day in the Life of a Renal Pathologist

8:30-10:00am: I get to work and have some coffee. For most physicians, this time of day is devoted to research, reading & writing, teaching conferences or even dropping the kids off at school. As the Physician Chief at Arkana, my mornings are usually filled with meetings. My meetings typically are with members of the physician team who have areas of responsibility they oversee or with the content team where we create all the content you see on Arkana’s Twitter/Facebook and Blog. One day a week I try to devote this time to my research projects.  10:00-11:00am: I attend our daily case conference...

Diagnose This (February 17, 2020)

Question: What is the Diagnosis?   ​   ​ ​   ​   ​ ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​ ​     ​   ​ ​   ​   ​ ​   ​   ​  ...

Twitter Poll (February 12th)

Answer: C Transplant glomerulopathy (TG) is characterized by duplication of glomerular basement membrane (GBM) and is graded based on the percentage of glomerular capillary loops with GBM duplication or double contours in the most affected non-sclerotic glomerulus by LM. TG often indicates the presence of chronic antibody mediated rejection, for which there will be glomerulitis (B), C4d positivity in PTCs (C), and mesangial matrix increase (A).  These findings are not in isolation from one another, therefore, "all of the above" would also be a correct answer. The Banff Lesion Score cg is based on the presence and extent of GBM double...

Twitter Poll (February 5, 2020)

ANSWER: D 2,8-dihydroxyadeninuria (DHA) disease is a rare autosomal recessive disorder caused by complete adenine phosphoribosyltransferase (APRT) deficiency and manifests as recurrent nephrolithiasis. 2,8-DHA can lead to irreversible renal failure and frequently recurs in the transplants. For the blog: Adenine phosphoribosyltransferase (APRT) deficiency is a rare autosomal recessive inherited disorder of purine metabolism. APRT catalyzes the formation of adenosine monophosphate from adenine. In the absence of APRT activity, adenine is catabolized by xanthine oxidase to 2,8-dihydroxyadenine (DHA), which is excreted in the urine. DHA is insoluble in the urine at the physiological range of pH, which may lead to crystalluria....

Anti-Brush Border Antibody Disease (ABBA)

What is your diagnosis?    ​ ​   ​   ​ ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​ ​   ​ ​   ​ ​   ​ ​     ​   ​   ​ ​   ​...

Fellowing Joel- Episode 15

Fellowing Joel, Arkana Laboratories, Renal Pathology, fellowship program
Big things in store for our fellow in 2020!   Dr. Murphy explains what all is happening this year on Episode 15 of Fellowing Joel!   [video width="1920" height="1080" mp4=""][/video]

Fellowing Joel – Episode 14

Fellowing Joel, Arkana Laboratories, Renal Pathology, fellowship program
Visitors, and journal clubs, and lectures! Oh, my! Dr. Murphy breaks down what's been happening in this week's Fellowing Joel episode.  [video width="1920" height="1080" mp4=""][/video]      

Dr. Jai Radhakrishnan Visit

We're so excited to have Dr. Jai Radhakrishnan of Columbia University visiting this week! He joined the Arkana Journal Club last night and gave a lecture on lupus nephritis this morning.

Fellowing Joel – Episode 13

Fellowing Joel, Arkana Laboratories, Renal Pathology, fellowship program
We caught up with Dr. Murphy as he was getting a tour of the Arkana Fish Lab in this week's Fellowing Joel episode. [video width="1920" height="1080" mp4=""][/video]