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IgA, IgA Differential, IgA nephropathy
Teaching Points

IgA Differential

IgA nephropathy is defined by IgA dominant or co-dominant deposits in glomeruli in the absence of systemic disease. Other diseases…

mild endocapillary hypercellularity with rare double contour formation of the capillary loops, Proliferative Glomerulonephritis with Monoclonal IgG Deposits
Teaching Points

Proliferative Glomerulonephritis with Monoclonal IgG Deposits

This biopsy was performed on an 81-year-male, status post renal transplant, who presented with increased creatinine (2.3 mg/dl) and microscopic…

Alport Syndrome Detected with IF
Teaching Points

Alport IF

In patients suspected of having Alport syndrome, immunofluorescence staining can be used to detect abnormal expression of various alpha chains…


extensive mesangial and subendothelial deposition of PAS-positive
Teaching Points

Fibronectin Glomerulopathy

A renal biopsy was performed in a 32-year-old female with microscopic hematuria and nephrotic range proteinuria of 4 grams per…

IgA Nephropathy
Diagnose This!

Diagnose This! (January 8, 2018)

The immunofluorescence image shown is of IgA. What is the most likely diagnosis and clinical history?   …

By L. Nich Cossey, MD
Crescentic Glomerulonephritis with IgA Deposits
Teaching Points

Crescentic Glomerulonephritis with IgA Deposits

This biopsy was taken from a 58-year-old male with no significant past medical history, who presents with gross hematuria, serum…


Cholesterol Microemboli
Teaching Points

Cholesterol Microemboli

Cholesterol emboli involving the kidney may manifest clinically as acute kidney injury, hematuria, proteinuria (both non-nephrotic and nephrotic range), and…

MEST-C, IgA with Crescents
Teaching Points

IgA with Crescents, MEST-C

This biopsy is from a young adult patient with IgA nephropathy (the immunofluorescence image in Fig. 2 shows 2+ mesangial…

Acute Post-Infectious Glomerulonephritis
Teaching Points

Acute Post-Infectious Glomerulonephritis

These renal biopsy images are from an 8-year-old boy who experienced the abrupt onset of hypertension, lower extremity edema, gross…


Alport Syndrome
Teaching Points

Alport Syndrome

This biopsy from a 22-year-old Hispanic male with a history of hematuria, subnephrotic proteinuria, and chronic kidney disease shows essentially…

IgA nephropathy
Diagnose This!

Diagnose This! (October 23, 2017)

This IF image is from a 22 y/o Asian male with hematuria. What immunoreactant does it represent and what is…

By L. Nich Cossey, MD
X-linked Alport syndrome
Teaching Points

Alport Skin

The most common form of Alport syndrome shows an X-linked dominant inheritance pattern and is caused by mutations in the…


Hematuria
Twitter Poll

Twitter Poll (October 18, 2017)

Answer B is the best answer. Hematuria, while possible, is an uncommon presenting symptom of membranous glomerulopathy.

By Vanessa Moreno, MD
Fabry disease
Teaching Points

Fabry Disease and IgA

A 34-year-old Asian female underwent a renal biopsy as part of the workup for progressively worsening renal function (Cr =…

Thrombotic Microangiopathy
Teaching Points

Thrombotic Microangiopathy

This biopsy is from a person in their 40s, who presented with accelerated hypertension and blood pressure of 240/180 mm/Hg.…

Patrick D. Walker, MD renal pathologist at arkana laboratories
By Patrick D. Walker, MD