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Antiphospholipid Antibody Syndrome
This biopsy shows glomerular arteriolar and capillary thrombi characteristic of thrombotic microangiopathy (TMA). Immunofluorescence studies (not shown) are negative for…
Granulomatous Interstitial Nephritis in CLL
This is a renal biopsy from a 62-year-old female with a recent diagnosis of CLL/SLL, who presents with rapidly worsening…
IgG4 Membranous
First identified in the pancreas as autoimmune pancreatitis, the IgG4-related disease is now known to affect many organs and body…
Membranous with FSGS
Some patients with membranous glomerulopathy also have associated focal segmental glomerulosclerosis (FSGS) lesions. The glomerulus in this biopsy image, for…
Crescentic Fibrillary Glomerulopathy
Fibrillary glomerulopathy is a rare disorder of unknown etiology and pathophysiology, which is characterized by deposition of course, randomly-oriented, non-branching…
IgA Nephropathy Oxford Scoring
TheIgA nephropathy Oxford Classification was first published in 2009 by a working group of nephrologists and renal pathologists representing the…
Evaluating Eosin-Stained Frozen Section Slides Using Fluorescence Microscopy
As published decades ago by Bonsib et al. (see reference), fluorescence microscopy of eosin-stained frozen section slides can be a…
Bile Stained Calcium Oxalate Crystals
A renal biopsy was performed on this 75-year-old female who presented with acute liver failure, jaundice and acute renal failure…
2,8 DHA Crystalline Nephropathy
The renal biopsy shown here has crystals present within the tubular lumens and cytoplasm with a brownish appearance by H&E…
Adenovirus
This allograft biopsy shows the characteristic features of adenovirus infection. There is prominent interstitial hemorrhage and edema (Fig. 1), acute…
PLA2R Tutorial
The diagnosis of membranous glomerulopathy has been transformed in the past 10 years with the discovery of PLA2R. PLA2R is…
Giant Cells
Sometimes the giant cells in granulomatous inflammation are truly giant!
Chronic Lesions of ANCA – Arteritis
The renal biopsy shown here is from a patient with a remote history of ANCA-associated vasculitis. The artery present in…
Chronic Active Antibody-Mediated Rejection
A diagnosis of chronic active antibody-mediated rejection (ABMR) requires morphologic evidence of chronic tissue injury (e.g. transplant glomerulopathy), evidence of…
Vascular-Limited AL Amyloidosis
A renal biopsy was performed on this 78 year old male with history of diabetes mellitus, hypertension and monoclonal gammopathy…