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Diagnose This!

Diagnose This 3/11/2024

What is your diagnosis in a patient with nephrotic syndrome? The electron photomicrograph demonstrates frequent subepithelial deposits along the glomerular…

NCAM1, Membranous Nephropathy, Lipoic Acid in NELL1-Associated Membranous Nephropathy, SARS-CoV-2, biopsy, TGFBR3, crystalline nephropathies, Renal Intratubular Casts, viral-like inclusions, Covid-19, Anti-Brush Border Antibody Disease, MGMID, renal pathology, kidney research
Podcast

How Times Have Changed! A Cornucopia of Antigens for Membranous Nephropathy

Membranous Nephropathy, or Membranous Glomerulopathy, is an autoimmune disease-causing nephrotic syndrome in which there is subepithelial deposition of IgG and…

By Dr. Rebecca May
NCAM1, Membranous Nephropathy, Lipoic Acid in NELL1-Associated Membranous Nephropathy, SARS-CoV-2, biopsy, TGFBR3, crystalline nephropathies, Renal Intratubular Casts, viral-like inclusions, Covid-19, Anti-Brush Border Antibody Disease, MGMID, renal pathology, kidney research
Podcast

NELL1 Is A Target Antigen In Malignancy-Associated Membranous Nephropathy

Membranous nephropathy is a leading cause of nephrotic syndrome. On renal biopsy, immunofluorescence shows granular capillary loop deposits, and holes…

By Dr. Rebecca May

MGMID
Disease Week

Disease Week: MGMID

Tuesday: Let’s start with a poll. You have a 25-year-old female patient with a positive ANA and proteinuria. On a…

Twitter Poll

Twitter Poll (June 9, 2021)

Answer: A, Minimal change disease Minimal change disease is classically seen in young children and usually is identified by a…

Scanning EM of a Proteinuric Glomerulus, eyescandy, renal pathology, arkana laboratories
eyeSCANdy

Scanning EM of a Proteinuric Glomerulus

This eyeSCANdy image shows scanning EM of a proteinuric glomerulus with capillary loop showing widening and partial loss of interdigitating…


Pediatric Nephrotic Syndrome, childhood nephrotic syndrome, CSA, CNI, juxtaglomerular apparatus
Teaching Points

Chronic Cyclosporine Toxicity in Pediatric Nephrotic Syndrome

This biopsy is from a 9-year-old boy who developed pediatric nephrotic syndrome in the first year of life and has…

What does minimal change disease look like?
Art of Medicine

Art of Medicine: Minimal Change Disease

The above painting shows podocytes with foot processes extending along the glomerular basement membrane of neighboring capillary loops. Effacement of…


diffuse foot process effacement, Minimal change disease, Nephrotic syndrome, Podocytopathy, Arkana Laboratories
Diagnose This!

Diagnose This (April 22, 2019)

What is this finding and what diagnoses does it imply?   …

By L. Nich Cossey, MD
Collapsing Glomerulopathy, APOL1, arkana laboratories, kidney disease, renal pathology
Twitter Poll

Twitter Poll (April 17, 2019)

ANSWER: D Collapsing glomerulopathy has been associated with certain infectious disease including HIV, Hepatitis C, HTLV-1, parvovirus B19, cytomegalovirus, tuberculosis,…

By Vanessa Moreno, MD
Nephrotic Syndrome, Arkana Laboratories, renal pathology, kidney injury
By L. Nich Cossey, MD

IgA nephropathy in renal biopsy from Arkana Laboratories
Teaching Points

IgA nephropathy with something extra…

The biopsy is from a 61-year-old man with a history of intermittent microscopic hematuria for many years who presents with…

Minimal Change Disease
Diagnose This!

Diagnose This (October 29, 2018)

What class of disease does this patient have and how did they present clinically?         …

By L. Nich Cossey, MD
ANCA Disease, LECT2 Amyloid, IgG4-Related Disease, AL amyloidosis, ANCA, digging deeper, Dr. Messias, Arkana Laboratories, pathology diseases
Digging Deeper

One little, two little, three little findings…

This biopsy came to us for evaluation of nephrotic syndrome. The patient is a Hispanic gentleman in his late 80s,…

By Nidia Messias, MD